Working memory deficits in multiple sclerosis: a controlled study with auditory P600 correlates.
نویسندگان
چکیده
BACKGROUND Recently, the P600 component of event related potentials, a waveform that is conceived to be generated and/or modulated by basal ganglia and cingulate area has been considered an index of the completion of any synchronised operation after target detection, having much in common with working memory operation. Moreover, dysfunction of these brain structures as well as working memory deficits have been implicated in the pathophysiology of multiple sclerosis. The aim of this study was to investigate the patterns of P600 elicited during a working memory test in multiple sclerosis patients compared with healthy controls. METHODS Twenty two definite, chronic progressive multiple sclerosis patients, with recent exacerbation of their illness, and 20 normal subjects matched for age, sex, and educational level, were studied with a computerised version of the digit span test of Wechsler batteries. Auditory P600 were measured during the anticipatory period of this test. RESULTS The patient group, as compared with healthy controls, showed significantly reduced latencies of P600 at left frontal areas and reduced P600 amplitudes at left temporoparietal region. Moreover, memory performance of patients was significantly more impaired when compared with healthy controls. CONCLUSIONS These findings may indicate that multiple sclerosis is associated with abnormal features of the completion of synchronised operation after target detection, as they are reflected by P600 amplitudes and latencies. Dysfunction of this mechanism may contribute to the identification of basic cognitive processes that could account for the cognitive deficits in multiple sclerosis.
منابع مشابه
تأثیر توانبخشی توجه، در کاهش نقایص توجه متمرکز و حافظه کاری در مبتلایان به مالتیپل اسکلروزیس
Background & Aims: Multiple sclerosis (MS) is a progressive central nervous system (CNS) disease. Cognitive impairment is a common concomitant of multiple sclerosis that affects various aspects of cognitive functioning including attention, and memory. Few studies investigated the efficacy of attention rehabilitation to decrease attention deficits in multiple sclerosis patients. The present s...
متن کاملRelation between Working Memory Capacity and Auditory Stream Segregation in Children with Auditory Processing Disorder
Background: This study assessed the relationship between working memory capacity and auditory stream segregation by using the concurrent minimum audible angle in children with a diagnosed auditory processing disorder (APD).Methods: The participants in this cross-sectional, comparative study were 20 typically developing children and 15 children with a diagnosed APD (age, 9–11 years) according to...
متن کاملThe Effect of Working Memory Training on Auditory Stream Segregation in Auditory Processing Disorders Children
Objectives: This study investigated the efficacy of working memory training for improving working memory capacity and related auditory stream segregation in auditory processing disorders children. Methods: Fifteen subjects (9-11 years), clinically diagnosed with auditory processing disorder participated in this non-randomized case-controlled trial. Working memory abilities and auditory strea...
متن کاملEffectiveness of Attention Rehabilitation on Decreasing Selective Attention Deficits in Patients with Multiple Sclerosis
Objective: Multiple sclerosis (MS) is a progressive disease of CNS and cognitive impairment is a common concomitant of it that affects various aspects of cognitive functioning like attention and memory as well as attentional complex tasks such as selective attention. The present study investigated the effectiveness of attention rehabilitation on decreasing selective attention deficits in patien...
متن کاملبررسی اثربخشی نوروفیدبک همراه با تمرینهای شناختی رایانهای در بهبود حافظه فعال در بزرگسالان دارای اختلال نقص توجه/بیش فعالی
Background : Attention deficit / hyperactivity disorder, is a common psychological disorder in persons, that continues from childhood into adulthood and leads to problem in various aspects of their life, such as personal, social, professional, and executive function such as working memory. Several studies indicate a close relationship between working memory deficits and attention de...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 74 9 شماره
صفحات -
تاریخ انتشار 2003